In particular, a successful resolution of injury-induced inflammation requires the continuous balance of hormonal and genetic factors. The essential hormones involved in the process are eicosanoids derived from omega-6 fatty acids that need to be balanced by resolvins derived from omega-3 fatty acids. Likewise, the gene transcription factor NF-κB that controls inflammation must be offset by the activation of AMPK, which is the genetic master switch of metabolism and repair of damaged tissue.
“This balancing act of initiation of inflammation and its ultimate resolution that leads to healing is a systems-based approach,” states Dr. Barry Sears, the President of the Inflammation Research Foundation. “The activation of resolution requires a sequential orchestration of reducing, resolving, and repairing of the injury-induced inflammation. Each step of the process can be either enhanced or inhibited by the diet.”
The article outlines an appropriate calorie-restricted anti-inflammatory diet that is needed to reduce inflammation, the levels of omega-3 fatty acids required to resolve inflammation, and the levels of dietary polyphenols required to activate AMPK to repair the tissue damage caused by the inflammation. Furthermore, the appropriate blood markers to indicate success in optimizing each distinct phase of resolution are discussed in the article.
Since injuries are at random, the mechanisms and dietary constraints required for their successful orchestration leading to healing must be continually optimized. If not, then unresolved inflammation may become permanent in the form of either fibrosis or the development of senescence cells leading to earlier onset of chronic disease and acceleration of the aging process.