ROCHESTER, MN – Nearly a third of patients responding to a Mayo Clinic survey said they used none of the opioids they were prescribed after surgery. The research findings, presented Thursday, April 19 at the American Surgical Association annual meeting, also show that only about 8 percent of patients disposed of their remaining opioids.
Can medical marijuana help to fight the opioid epidemic? Many believe that it can. But a new study finds that people who use medical marijuana actually have higher rates of medical and non-medical prescription drug use—including pain relievers. The study appears in the Journal of Addiction Medicine, the official journal of the American Society of Addiction Medicine (ASAM), published by Wolters Kluwer.
TORONTO – According to a new national policy paper released today by the Canadian Mental Health Association (CMHA), decriminalization is key to solving the opioid crisis that is killing thousands of people. The paper, developed by a cross-Canada team of mental health policy and research experts in response to escalating rates of opioid-related harms, recommends a bold and effective public health approach to relieving the crisis that focuses on care, not corrections.
HAMILTON, ON—A new study from McMaster and York universities has found that poor muscle health may be a complication of Type 1 diabetes, even among active twenty-somethings.The research team analyzed muscle biopsies of young adults with and without Type 1 diabetes who exceed Diabetes Canada's recommended weekly levels for physical activity.The researchers found structural and functional changes in the power generation parts of the cell, or mitochondria, of those with diabetes. Not only were the mitochondria less capable of producing energy for the muscle, they were also releasing high amounts of toxic reactive oxygen species, related to cell damage.These changes could result in reduced metabolism, greater difficulty controlling blood glucose and, if left unchecked, an accelerated rate of developing disability. The study findings add poor muscle health to the list of better-known complications of Type 1 diabetes, including nerve damage, heart disease and kidney disorders."Now we know that even active people with diabetes have changes in their muscles that could impair their ability to manage blood sugar," said Thomas Hawke, corresponding author of the study and a professor of pathology and molecular medicine at McMaster. "Knowing in the long term that this could contribute to faster development of disability, we can start to address it early on."Christopher Perry, study co-senior author and an associate professor in kinesiology and health sciences and the Muscle Health Research Centre at York University, added: "Skeletal muscle is our largest metabolic organ and is the primary tissue for clearing blood sugar after eating a meal, so we need to keep muscle as healthy as possible."With regular aerobic exercise, the amount of mitochondria in muscle increases, thereby helping muscle cells to use more glucose and become more efficient. Given this new data, Perry added that their study suggests that current guidelines for Type 1 diabetics may also need to be revised."We believe these dysfunctional mitochondria are what's causing the muscle to not use glucose properly and to also damage muscle cells in the process. We were surprised to see the muscles were this unhealthy in young adults with Type 1 diabetes who were regularly active."Researchers say while further study is needed, revising evidence-based exercise guidelines, specific for those with Type 1 diabetes, may be required to keep them in the best health.The paper was published today in Diabetologia, the journal of the European Association for the Study of Diabetes. The study may be found HERE.The team included researchers at York University, the University of Windsor and the German Center for Neurodegenerative Diseases as well as McMaster's departments of pathology and molecular medicine, pediatrics and kinesiology. Both Hawke and Perry are on the Board of Directors for the Canadian Society for Exercise Physiology.The study was funded in part by the Natural Sciences and Engineering Research Council of Canada, the Canada Foundation for Innovation, and the James H. Cummings Foundation.
Of the more than 38 million Americans who experience migraine headaches, 28 million are women. Compared to men, women also experience more frequent and severe migraines and don't respond as well to drug treatments. Findings from a new study conducted in rats reveal that females may be more susceptible to migraines and less responsive to treatment because of the way fluctuations in the hormone estrogen affect cells in the brain.Emily Galloway, an undergraduate research assistant in the laboratory of Tally Largent-Milnes in the Department of Pharmacology at the University of Arizona in Tucson, presented this research at the American Society for Biochemistry and Molecular Biology annual meeting during the 2018 Experimental Biology meeting held April 21-25 in San Diego."Conducting research on the molecular mechanisms behind migraine is the first step in creating more targeted drugs to treat this condition, for men and women," said Galloway. "Knowledge gained from this work could lead to relief for millions of those who suffer from migraines and identify individuals who may have better responses to specific therapies."The new study is one of the first to examine the role of the sodium proton exchanger NHE1 in migraine headaches. NHE1 regulates the transport of protons and sodium ions across cell membranes, including those that make up the blood-brain barrier. When NHE1 isn't present at high enough levels or doesn't function properly, it can cause increased pain signaling that leads to a migraine. Problems with NHE1 can also directly alter the ability of migraine drugs to cross the blood-brain barrier.Even though women are much more likely to experience migraines than men, most migraine research is conducted using male animal models. In the new study, the researchers examined both male and female rats and found NHE1 expression levels were four times higher in the brains of the male rats. In the female rats, they observed that the highest estrogen levels corresponded with the lowest levels of NHE1 expressed in the endothelial cells that form the blood vessels in the brain."Based on our findings, we think that women are more susceptible to migraine because the larger magnitude sex hormone fluctuations lead to changes in NHE1 expression, which may leave the brain vulnerable to ion dysregulation and pain activation," said Galloway.The new work is part of an effort to create a molecular map of how sex hormones affect NHE1 expression. In the future, the researchers want to see if drugs that target certain players in this map would prevent dysregulation of NHE1 expression at the blood brain barrier. This could lead to new treatments for people who suffer from migraines.
A recent study released by the Journal of Occupational and Environmental Medicine shows a stunning number of participants not only experienced concussion-related symptoms and head impacts but also continued performing either without reporting the incident or without receiving the recommended care. These participants were not taking part in any sporting contest at the time, however. They are theater personnel.
People whose negative emotional responses to stress carry over to the following day are more likely to report health problems and physical limitations later in life compared with peers who are able to "let it go," according to findings published in Psychological Science, a journal of the Association for Psychological Science.
According to the Canadian Cancer Society, massage therapy is one of the most popular complementary therapies utilized by people living with cancer. While there is no evidence that suggests massage therapy can treat this disease, it is recognized for its efficacy in providing physical and emotional benefits to the cancer patient, helping improve their quality of life.
Australian scientists say they have edged closer to developing new pain relief medication from sea snails.
DURHAM, N.C. — For decades, Americans have been inundated with a confusing barrage of messages about how best to counteract the health risks of sedentary lifestyles: walk 10,000 steps a day; do a seven-minute workout from a phone app; flip heavy tires in an arduous boot camp class.
In a recent report by Doctor Francis D' Ambrosio, medical marijuana patients most successfully replaced medication with marijuana for a variety of different conditions, including cancer, epilepsy, depression, anxiety and post-traumatic stress disorder (PTSD).
The war on drugs may move to a new battlefield in Canada, if Liberal MPs get their way: the 2019 federal election campaign.
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Pregnancy Massage Therapy Foundations
June 2, 2018
Canadian Mental Health Association Ride Don't Hide
June 24, 2018
American Massage Therapy Association 2018 National Convention
August 9-11, 2018
5th International Fascia Research Congress
November 14-15, 2018